|
KMID : 0811720180220010017
|
|
Korean Journal of Physiology & Pharmacology
2018 Volume.22 No. 1 p.17 ~ p.21
|
|
|
Morroniside on anti-inflammation activities in rats following acute myocardial infarction
|
|
Yu Bang Xing
Zhang Guo Xing
An Yi
Wang Wen
|
|
|
Abstract
|
|
|
|
Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits. The expression of IL-6, IL-1β and TNF-α in myocardium was detected by Western blotting analysis. We observed a significant decline in the Q(q) wave amplitude in morroniside-treated rats after 72 h. Additionally, treatment of morroniside decreased the levels of LDH and cTnT in AMI rats. We also observed that morroniside reduced the expression of IL-6, IL-1β and TNF-α in myocardium. Taken together, our findings demonstrate that morroniside had effective anti-in?ammatory properties in AMI rats.
|
|
|
KEYWORD
|
|
|
Acute myocardial infarction, Cytokine, Inflammation, Morroniside
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|